Characterisation and phylogenetic analysis of the VP7 proteins of serotype G6 and G8 human rotaviruses.

摘要: Serotype G6 and G8 rotaviruses are rarely found in man may have originated animals. Human serotype rotaviruses, isolated from hospitalised children at various locations Australia, were characterised. Deduced amino acid sequences of the major neutralising antigen, V7, showed significant identity to cognate proteins prototype human bovine viruses, respectively, strains reacted with serotype-specific monoclonal antibodies, an enzyme immunoassay. The VP4 type was determined as P[14] for all tested. Phylogenetic analysis these other VP7 suggested that a single inter-species transmission event, possibly cattle, led emergence viruses man. In contrast, exchange genes between occurred on more than one occasion, or different host.