N-Hydroxypyridine-2-thione

摘要: [1121-30-8] C5H5NOS (MW 127.18) (reaction with a carboxylic acid or chloride leads to the corresponding O-acyl thiohydroxamate; treatment of these intermediates radical source alkyl aryl radicals [Rċ], fate which depends on precise reactions conditions1) Alternate Name: 1-hydroxy-2-(1H)-pyridinethione; tautomeric ‘N-oxide’ form [1121-31-9], although minor component, is often alternate names for this compound, include 2-pyridinethiol 1-oxide, 2-mercaptopyridine N-oxide, and abbreviated ‘pyrithione’. Physical Data: mp 70–72 °C. Form Supplied in: both pyridinethione sodium salt (sometimes as hydrate) are commercially available. A 40% aqueous solution also available cheaper (also referred omadine). The free thione can be obtained from by acidification neutrality using concentrated aq HCl, filtration crude product, crystallization EtOH. Alternatively, evaporation (<50 °C) residue ethanol provides salt, mp 285–290 °C, after slow drying at 50 °C under vacuum.3 Preparative Methods: prepared 2-bromopyridine oxidation N-oxide either Perbenzoic Acid Peracetic Acid, followed displacement bromide Sodium Dithionite Sulfide Hydroxide.2 An alternative treat Thiourea then hydrolyze resulting thiouronium salt. Handling, Storage, Precautions: all operations in area should carried out due regard both thermal photochemical sensitivity reagents intermediate thiohydroxamates.