NEUROBIOLOGICAL PREDICTORS OF RESPONSE TO DORSOLATERAL PREFRONTAL CORTEX REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION IN DEPRESSION: A SYSTEMATIC REVIEW

摘要: Background A significant proportion of patients with depression fail to respond psychotherapy and standard pharmacotherapy, leading treatment-resistant (TRD). Due the prevalence TRD, alternative therapies for have emerged as viable treatments in armamentarium this disorder. Repetitive transcranial magnetic stimulation (rTMS) is now being offered clinical practice broader numbers. Many studies investigated various different neurobiological predictors response rTMS. However, a synthesis literature an understanding what biological targets predict lacking. This review aims systematically synthesize on rTMS depression. Methods Medline (1996–2014), Embase (1980-2014), PsycINFO (1806-2014) were searched under set terms. Two authors reviewed each article came consensus inclusion exclusion criteria. All eligible reviewed, duplicates removed, data extracted individually. Results The search identified 1,673 articles, 41 which met both Various factors at baseline appear rTMS, including levels certain molecular factors, blood flow brain regions implicated depression, electrophysiological findings, specific genetic polymorphisms. Conclusions Significant methodological variability treatment protocols limits ability generalize conclusions. may be predicted by frontal lobe flow, presence polymorphisms 5-hydroxytryptamine (5-HT) -1a gene, LL genotype serotonin transporter linked polymorphic region (5-HTTLPR) Val/Val homozygotes brain-derived neurotrophic factor (BDNF) gene.