Exploring ribosome composition and newly synthesized proteins through proteomics and potential biomedical applications.

摘要: ABSTRACTIntroduction: Protein synthesis is the outcome of tightly regulated gene expression which responsive to a variety conditions. Efforts are ongoing monitor individual stages protein ensure maximum efficiency and accuracy. Due post-transcriptional regulation mechanisms, correlation between translatome proteome higher than transcriptome proteome. However, most accurate approach assess key modulators final directly by using proteomics.Areas covered: This review covers various proteomic strategies that were used better understand regulation, specifically during early after translation. The methods identify both regulatory proteins associated with translational components newly synthesized discussed.Expert commentary: Emerging approaches make it possible dynamics in cells, tissues whole animals. ability detect alteration prote...