Oxysterols and Alzheimer's disease.

摘要: There is a clear link between cholesterol turnover and neurodegenerative diseases hypercholesterolemia an established risk factor for Alzheimer's disease (AD). The failure to demonstrate transfer of from the circulation into brain in humans experimental animals makes it difficult explain AD. In contrast itself, side-chain oxidized metabolites such as 24S-hydroxycholesterol 27-hydroxycholesterol are able pass blood-brain barrier (BBB). Formation quantitatively most important mechanism elimination we recently demonstrated significant net uptake by circulation. We have also shown that patients with AD increased levels 27-hydroxycholesterol, which may affect production β-amyloid brain. correlated possibility must be considered flux missing disease. Current knowledge about role two oxysterols homeostasis well their diagnostic potential reviewed.