Network Analysis Reveals Functional Cross-links between Disease and Inflammation Genes
作者： Yunpeng Zhang , Huihui Fan , Juan Xu , Yun Xiao , Yanjun Xu
DOI: 10.1038/SREP03426
关键词:
摘要: Connections between inflammation and diseases are suggested important in understanding the genetic mechanisms of diseases. However, studies on functional cross-links disease genes still their early stages. We integrated protein-protein interaction (PPI), genes, gene-disease associations to construct a disease-inflammation network (DIN). found that nodes, which both (namely inter-genes), topologically DIN structure. Via mapping inter-genes PPI, we classified into two categories, significantly different Intimacy measuring contribution connections pairs. Furthermore, constructed cross-talking subpathways network. As indicated, cross-subpathway analysis shows great performance capturing higher-level relationship among processes. Collectively, The network-based provides us rather promising insight intricate genes.
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