Bioavailability Enhancement of Polymyxin B With Novel Drug Delivery: Development and Optimization Using Quality-by-Design Approach.

摘要: Abstract Polymyxin-B (Poly-B) is an effective antibiotic used to treat infections mainly caused due sensitive gram-negative bacteria. They belong the group of cyclic peptide antibiotics and are minimally absorbed from gastrointestinal tract. This arises need for bioavailability enhancement achieved in present case using niosomes as carrier system. The Poly-B had been developed Span 60 cholesterol while optimization with quality-by-design (QBD) approach. In this QBD approach, 3 independent variables (Span 60:cholesterol, volume phosphate-buffered saline [%], amount drug [mg]) each at levels were studied. A total 17 runs suggested by model which was further analyzed optimizing different responses (particle size, zeta potential, entrapment efficiency [EE%]). results clearly shown that optimum formulation selected based on criteria attaining maximum value EE% low size potential. examined in vitro antifungal, rat creatinine, cytotoxicity assay. pharmacokinetics scintigraphy studies also performed in vivo behavior Poly-B.