Present and future therapeutic strategies for idiopathic oligozoospermia

摘要: The effectiveness of medical treatment for idiopathic oligozoospermia (IO) has been at best doubtful until now and a logical consequence this unsatisfactory situation the partial displacement approach by assisted reproduction techniques. This state affairs resulted from insufficient investigation, inappropriately designed clinical trials consistent disregard principles evidence-based medicine. Protocol-related shortcomings wrong interpretation data available have also some all too frequent problems encountered in therapeutic approach. In rather misty situation, it appears that, agents used so far, follicle stimulating hormone (FSH) (mainly FSH-secretagogues) may exert beneficial effects on number biological endpoints related to spermatogenesis sperm maturation. short medium term prospects IO rest mainly with improvement investigative procedures higher degree sophistication, emphasis placed identifying causes than results dysfunction that better selection candidates can be made. Moreover, introduction prognostic indices evaluation agent paramount importance. Finally, assessment preparations and, possibly, new more specific an important step forward field. type large-scale effort should not left individual investigators or special centres working independently, but come under auspices central regulating agency undisputed large, multicentre uniform studies might obtained, if is remain good option. context, emphasized andrology's main task always treat male problem his healthy female partner, whenever possible.