Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

作者: Zhiyou Fang , Zhiyou Fang , Haoran Yang , Xueran Chen , Xueran Chen

DOI: 10.1186/S13287-021-02175-2

关键词:

摘要: … In the siRNA experiments, 300 nm siRNA oligonucleotides were … GP130, low-density lipoprotein receptor-related protein 12 (LRP12), … with GP130, but not with LRP12 and RIF1 (Fig. 4c). …

参考文章(59)
B.M. Lee, J.P. Cata, Impact of anesthesia on cancer recurrence. Revista española de anestesiología y reanimación. ,vol. 62, pp. 570- 575 ,(2015) , 10.1016/J.REDAR.2015.04.003
Sébastien Roger, Ludovic Gillet, Jean-Yves Le Guennec, Pierre Besson, Voltage-gated sodium channels and cancer: is excitability their primary role? Frontiers in Pharmacology. ,vol. 6, pp. 152- 152 ,(2015) , 10.3389/FPHAR.2015.00152
Sharon M. Gordon, Anastasia V. Mischenko, Raymond A. Dionne, Long-acting local anesthetics and perioperative pain management. Dental Clinics of North America. ,vol. 54, pp. 611- 620 ,(2010) , 10.1016/J.CDEN.2010.06.002
Dirk Graf, Caroline Kohlmann, Katrin Haselow, Thor Gehrmann, Johannes G. Bode, Dieter Häussinger, Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and -independent pathways in rat liver Hepatology. ,vol. 44, pp. 1206- 1217 ,(2006) , 10.1002/HEP.21368
Xueran Chen, Zhaoxia Du, Wei Shi, Chen Wang, Yang Yang, Fen Wang, Yao Yao, Kun He, Aijun Hao, 2-Bromopalmitate modulates neuronal differentiation through the regulation of histone acetylation. Stem Cell Research. ,vol. 12, pp. 481- 491 ,(2014) , 10.1016/J.SCR.2013.12.010
Yan Liu, Chenglong Li, Jiayuh Lin, STAT3 as a Therapeutic Target for Glioblastoma. Anti-cancer Agents in Medicinal Chemistry. ,vol. 10, pp. 512- 519 ,(2010) , 10.2174/187152010793498636
Ryouhei Tsutsumi, Yuko Fukata, Masaki Fukata, Discovery of protein-palmitoylating enzymes. Pflügers Archiv: European Journal of Physiology. ,vol. 456, pp. 1199- 1206 ,(2008) , 10.1007/S00424-008-0465-X
C. Boiteux, I. Vorobyov, R. J. French, C. French, V. Yarov-Yarovoy, T. W. Allen, Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 13057- 13062 ,(2014) , 10.1073/PNAS.1408710111
Y Wang, G M Fuller, Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes. Molecular Biology of the Cell. ,vol. 5, pp. 819- 828 ,(1994) , 10.1091/MBC.5.7.819
Justyna Korycka, Agnieszka Łach, Elżbieta Heger, Dżamila M. Bogusławska, Marcin Wolny, Monika Toporkiewicz, Katarzyna Augoff, Jan Korzeniewski, Aleksander F. Sikorski, Human DHHC proteins: a spotlight on the hidden player of palmitoylation. European Journal of Cell Biology. ,vol. 91, pp. 107- 117 ,(2012) , 10.1016/J.EJCB.2011.09.013