Evidence for the Importance of Peripheral Tissue Events in the Development of Hirsutism in Polycystic Ovary Syndrome
作者： ROGERIO A. LOBO , UWE GOEBELSMANN , RICHARD HORTON
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摘要: Hirsutism can occur in the presence of normal or near levels serum testosterone, unbound testosterone (uT), dehydroepiandrostene sulfate, androstenedione, and dihydrotestosterone. However, we have found that androstanediol glucuronide (3α-diol G) is markedly increased idiopathic hirsutism it serves as an excellent marker peripheral androgen metabolism action. In present work, studied 12 hirsute (H) nonhirsute (NH) patients with polycystic ovary syndrome (PCO) 13 age weight matched controls order to determine if differences sex steroid tissue events were associated hirsutism. Serum estradiol LHFSHratios similar both groups women PCO, significantly higher than (P < 0.05). Whereas uT, androstenedione elevated H-PCO NH-PCO compared controls, these two similar. dehydro...
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