Tolazoline therapy for persistent pulmonary hypertension after congenital diaphragmatic hernia repair

摘要: To determine whether vasodilators are useful in persistent pulmonary hypertension associated with congenital diaphragmatic hernia, we reviewed the clinical course, laboratory data, and outcome of 37 patients respiratory distress hernia requiring an operation before 24 hours life. These were divided into two groups, Group I (n=17) included treated prior to use tolazoline; II (n=20) those after tolazoline became available. Postoperative severe was observed ten I, all died. In II, 16 had postoperative four survived; 12 these received tolazoline, including survivors. Treated survivors significantly higher increase Pa o 2 a test dose than did nonsurvivors. A transient "honeymoon period" adequate oxygenation correlated good response presence both predictive survival. No patient survived combination no whereas without honeymoon period sometimes followed by All nonsurvivors lung hypoplasia at autopsy.