Behavioral differences among fourteen inbred mouse strains commonly used as disease models.

作者: Gerald W. M. Bothe , Valerie J. Bolivar , James G. Geistfeld , Michelle J. Vedder

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摘要: We compared the behavior of 14 inbred mouse strains and an F1 hybrid commonly used in transgenic knockout production. These were 129P3/J, 129S1/SvImJ, 129S6/SvEvTac, 129T2/SvEmsJ, 129X1/SvJ (formerly 129/J, 129/Sv-p+Tyr+Kitl+/J, 129/SvEvTac, 129SvEmsJ, 129/SvJ, respectively), A/JCrTac, BALB/cAnNTac, C3H/HeNTac, C57BL/6J, C57BL/6NTac, DBA/2NTac, FVB/NTac, NOD/MrkTac, SJL/JCrNTac, B6129S6F1Tac. Performance three behavioral tests (rotorod, open-field activity-habituation, contextual cued fear conditioning) was determined. On rotorod assay, SJL/JCrNTac mice had shortest latencies to fall on first day testing, DBA/2NTac showed impaired motor learning. Open-field analyzed using parameters total distance, center velocity, vertical activity. 129T2/EvEmsJ A/JCrTac least active open field, whereas NOD/MrkTac most active. Contrary earlier studies, we found that all habituated field at one these parameters. In conditioning, displayed activity suppression. However, FVB/NTac reacted less strongly both context cue than did other strains. There no significant differences between C57BL/6J except for higher female mice. findings illustrate importance appropriate selection background strain transgenic, gene targeting, or drug research.

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