Biochemistry of Aromatase: Significance to Female Reproductive Physiology

摘要: Abstract The formation of estrogens in mammals via aromatase involves the relatively unique capacity to form an aromatic ring de novo contrast most other substances (essential amino acids) which are obtained only diet. reaction is example a cytochrome P-450 system resides both mitochondrial and microsomal fractions cell. It occurs widely throughout body diverse tissues functions synthesis transformation prehormones (androstenedione testosterone). found animal species brain gonads even phylogenetically primitive species. Placental appears be associated with evolution viviparity extended gestational period utero. Follicular dependent upon follicle-stimulating hormone stimulation essential for oogenesis, ovulation, normal luteal while central nervous serves determine sexual behavior neurohormonal link hypothalamus pituitary ovarian cyclicity. While key pituitary, breast, endometrial growth development, this one few examples endogenous steroid that has been implicated as carcinogen or stimulant carcinogenesis.