Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.

作者: Qiang Zhou , Renhong Yan , Yuanyuan Zhang , Yaning Li , Lu Xia

DOI: 10.1126/SCIENCE.ABB2762

关键词:

摘要: … the presence of the neutral amino acid transporter B 0 AT1 with or without the receptor binding domain (RBD) of the … , with a local resolution of 3.5 angstroms at the ACE2-RBD interface. …

参考文章(55)
Luca Mastroberardino, Benjamin Spindler, Rahel Pfeiffer, Patrick J. Skelly, Jan Loffing, Charles B. Shoemaker, François Verrey, Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family Nature. ,vol. 395, pp. 288- 291 ,(1998) , 10.1038/26246
Heng F Seow, Stefan Bröer, Angelika Bröer, Charles G Bailey, Simon J Potter, Juleen A Cavanaugh, John E J Rasko, Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19 Nature Genetics. ,vol. 36, pp. 1003- 1007 ,(2004) , 10.1038/NG1406
S. Belouzard, V. C. Chu, G. R. Whittaker, Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 5871- 5876 ,(2009) , 10.1073/PNAS.0809524106
Wenhui Li, Michael J. Moore, Natalya Vasilieva, Jianhua Sui, Swee Kee Wong, Michael A. Berne, Mohan Somasundaran, John L. Sullivan, Katherine Luzuriaga, Thomas C. Greenough, Hyeryun Choe, Michael Farzan, Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. ,vol. 426, pp. 450- 454 ,(2003) , 10.1038/NATURE02145
Lawrence S. Zisman, Rebecca S. Keller, Barbara Weaver, Qishan Lin, Robert Speth, Michael R. Bristow, Charles C. Canver, Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles Evidence for Upregulation of the Angiotensin-Converting Enzyme Homologue ACE2 Circulation. ,vol. 108, pp. 1707- 1712 ,(2003) , 10.1161/01.CIR.0000094734.67990.99
Angelika Bröer, Karin Klingel, Sonja Kowalczuk, John E. J. Rasko, Juleen Cavanaugh, Stefan Bröer, Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder Journal of Biological Chemistry. ,vol. 279, pp. 24467- 24476 ,(2004) , 10.1074/JBC.M400904200
Mohan K Raizada, Anderson J Ferreira, ACE2: A New Target for Cardiovascular Disease Therapeutics Journal of Cardiovascular Pharmacology. ,vol. 50, pp. 112- 119 ,(2007) , 10.1097/FJC.0B013E3180986219
Fang Li, Wenhui Li, Michael Farzan, Stephen C Harrison, Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor Science. ,vol. 309, pp. 1864- 1868 ,(2005) , 10.1126/SCIENCE.1116480
Aravind Penmatsa, Kevin H. Wang, Eric Gouaux, X-ray structure of dopamine transporter elucidates antidepressant mechanism Nature. ,vol. 503, pp. 85- 90 ,(2013) , 10.1038/NATURE12533
Jean Kaoru Millet, Gary R Whittaker, None, Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis Virus Research. ,vol. 202, pp. 120- 134 ,(2015) , 10.1016/J.VIRUSRES.2014.11.021