In vitro analysis of iron chelating activity of flavonoids.

摘要: Flavonoids have been demonstrated to possess miscellaneous health benefits which are, at least partly, associated with iron chelation. In this in vitro study, 26 flavonoids from different subclasses were analyzed for their chelating activity and stability of the formed complexes four patho/physiologically relevant pH conditions (4.5, 5.5, 6.8, 7.5) compared clinically used chelator deferoxamine. The study that most effective binding site represents 6,7-dihydroxy structure. This is incorporated baicalein structure formed, similarly deferoxamine, stoichiometry 1:1 was not inferior all tested 3-hydroxy-4-keto conformation together 2,3-double bond catecholic B ring a substantial chelation although latter did play an essential role more acidic conditions. agreement, quercetin myricetin possessing three structural requirements active or deferoxamine neutral conditions, but clearly less lower pH. 5-hydroxy-4-keto efficient stable Isolated keto, hydroxyl, methoxyl groups ortho methoxy-hydroxy all.