The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver disease.
作者： Ivan R. Diamond , Anca Sterescu , Paul B. Pencharz , Paul W. Wales
DOI: 10.1007/S00383-008-2174-0
关键词:
摘要: Parenteral nutrition associated liver disease (PNALD) is the major source of morbidity and mortality in children with short bowel syndrome (SBS). There emerging evidence that omega-6 fatty acids (ω6FA) within parenteral solution play a role PNALD their effects may be reversed or ameliorated by substitution omega-3 (ω3FA). This paper reviews mechanisms whereby ω3FAs influence improving bile flow, inhibiting steatosis, having immunomodulatory effects. The early clinical experience SBS briefly reviewed implications such, future directions are considered.
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