Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions.

摘要: Because collagen is a major component of the human atherosclerotic plaque, factors controlling synthesis may have profound influence on volume growth these intimal lesions. In arteries, we compared normal vs media intimas for type I gene expression using immunocytochemistry and in situ messenger RNA hybridization with subsequent correlations plaque topographical features. We also determined associations such proximity to monocyte/macrophages T lymphocytes. Type appears be upregulated plaques their underlying medias internal mammary arteries coronary diffuse thickenings. At least established advanced carotid plaques, focal especially prevalent fibrous cap vascularized regions. Although macrophages procollagen protein are both found no apparent spatial correlation between macrophage presence was within intimas. negatively associated cells. Thus, exhibit nonuniform patterns expression. biochemical determinants this yet determined, it conceivable that stimulatory/inhibitory cytokines other (eg hemodynamics) play important roles determining nature atherosclerosis.