System for electrophysiological measurements
作者： John Dodgson , Lars Thomsen , Rafael Taboryski , Jonatan Kutchinsky , John Shaw
DOI:
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摘要: The present invention relates to a high through-put system for determining and/or monitoring electrophysiological properties of ion channels channel-containing membranes, typically lipid membrane-containing structures such as cells. In particular, the provides substrate which means automatically positioning cells at measuring sites using electroosmotic flow in canals formed on or substrate. is generated and controlled by pumps integrated positioned relation thereto. Thereby, can be favourable measurement configuration plurality performing testing measurements. Also, main electric circuit measurements parallel.
lens.org 参考文章(15)
Bradley D. Neagle, Kirk S. Schroeder, High-throughput electrophysiological measurement apparatus ,(2000)
Terrell T. Gibbs, David H. Farb, Nader Yaghoubi, Cellular physiology workstations for automated data acquisition and perfusion control ,(2001)
Christian Schmidt, Horst Vogel, Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers ,(1998)
Nicholas Gerard Byrne, David Geraint Owen, High throughput screen ,(1999)
Charles R. Keese, Ivar Giaever, Cell substrate electrical impedance sensor with multiple electrode array ,(1991)
Jamil El-Ali, Anders Wolff, John Dodgson, Lars Thomsen, Dirk Reuter, Apparatus and method for determining and/or monitoring electrophysiological properties of ion channels ,(2000)
Gregory T. A. Kovacs, Multiplexed active biologic array ,(1997)
Frederick J. Sigworth, Kathryn G. Klemic, James F. Klemic, Mark A. Reed, Planar patch clamp electrodes ,(2001)
Erwin Neher, Bert Sakmann, Joe Henry Steinbach, The extracellular patch clamp: a method for resolving currents through individual open channels in biological membranes Pflügers Archiv: European Journal of Physiology. ,vol. 375, pp. 219- 228 ,(1978) , 10.1007/BF00584247
S.o slashed.ren-Peter Olesen, Palle Christophersen, Patch clamp apparatus and technique having high throughput and low fluid volume requirements ,(1995)