Myelination and the trophic support of long axons

作者: Klaus-Armin Nave

DOI: 10.1038/NRN2797

关键词:

摘要: In addition to their role in providing myelin for rapid impulse propagation, the glia that ensheath long axons are required maintenance of normal axon transport and long-term survival. This presumably ancestral function seems be independent membrane wrapping. Here, I propose ensheathing provide trophic support metabolically isolated, itself might cause such isolation. glial axonal integrity may relevant a number neurological psychiatric diseases.

参考文章(138)
Aidong Yuan, Roland G. Mills, James R. Bamburg, John J. Bray, Cotransport of glyceraldehyde-3-phosphate dehydrogenase and actin in axons of chicken motoneurons. Cellular and Molecular Neurobiology. ,vol. 19, pp. 733- 744 ,(1999) , 10.1023/A:1006953022763
Jan Xu, Shawei Chen, S. Hinan Ahmed, Hong Chen, Grace Ku, Mark P. Goldberg, Chung Y. Hsu, Amyloid-beta peptides are cytotoxic to oligodendrocytes. The Journal of Neuroscience. ,vol. 21, ,(2001) , 10.1523/JNEUROSCI.21-01-J0001.2001
LeRoy Kuehl, Earl N. Sumsion, Turnover of Several Glycolytic Enzymes in Rat Liver Journal of Biological Chemistry. ,vol. 245, pp. 6616- 6623 ,(1970) , 10.1016/S0021-9258(18)62578-5
Rüdiger Schweigreiter, Betty I. Roots, Christine E. Bandtlow, Robert M. Gould, Understanding myelination through studying its evolution. International Review of Neurobiology. ,vol. 73, pp. 219- 273 ,(2006) , 10.1016/S0074-7742(06)73007-0
Alastair Wilkins, Henry Majed, Robert Layfield, Alastair Compston, Siddharthan Chandran, Oligodendrocytes Promote Neuronal Survival and Axonal Length by Distinct Intracellular Mechanisms: A Novel Role for Oligodendrocyte-Derived Glial Cell Line-Derived Neurotrophic Factor The Journal of Neuroscience. ,vol. 23, pp. 4967- 4974 ,(2003) , 10.1523/JNEUROSCI.23-12-04967.2003
Thomas Uschkureit, Olaf Spörkel, Jens Stracke, Heinrich Büssow, Wilhelm Stoffel, Early Onset of Axonal Degeneration in Double (plp−/−mag−/−) and Hypomyelinosis in Triple (plp−/−mbp−/−mag−/−) Mutant Mice The Journal of Neuroscience. ,vol. 20, pp. 5225- 5233 ,(2000) , 10.1523/JNEUROSCI.20-14-05225.2000
Regina Wender, Angus M Brown, Robert Fern, Raymond A Swanson, Kevin Farrell, Bruce R Ransom, None, Astrocytic Glycogen Influences Axon Function and Survival during Glucose Deprivation in Central White Matter The Journal of Neuroscience. ,vol. 20, pp. 6804- 6810 ,(2000) , 10.1523/JNEUROSCI.20-18-06804.2000
D. Pareyson, V. Scaioli, M. Laurà, Clinical and electrophysiological aspects of Charcot-Marie-Tooth disease Neuromolecular Medicine. ,vol. 8, pp. 3- 22 ,(2006) , 10.1385/NMM:8:1-2:3
James L Salzer, None, Polarized Domains of Myelinated Axons Neuron. ,vol. 40, pp. 297- 318 ,(2003) , 10.1016/S0896-6273(03)00628-7