CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass.

摘要: AIM Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral increases, adiponectin levels decrease; therefore, provides a link between and disorders. Genome-wide association studies (GWASs) have identified genetic variations in cadherin 13 (CDH13) gene that are associated with levels. METHODS We investigated whether single nucleotide polymorphisms (SNPs) CDH13 was syndrome traits independent area (VFA), as measured using computed tomography (CT) 945 Japanese individuals. RESULTS found three SNPs reported by recent GWASs (i.e., rs3865188, rs4783244, rs12051272) were significantly higher (P ＜ 1 × 10 (-14)), even after adjustment for VFA. However, these adiponectin-inducing alleles consistent deteriorating symptoms, such fasting insulin, homeostasis model assessment-insulin resistance (HOMA-IR) scores, triglycerides lower high-density lipoprotein (HDL)-cholesterol levels, similar increasing VFA decreasing CONCLUSION These results suggested cause an adiponectin-resistant status compensate could result deterioration traits.