PROLONGATION OF CARDIAC XENOGRAFT SURVIVAL IN RATS RECEIVING CYCLOSPORIN A

摘要: SUMMARY The effect of cyclosporin A was tested in a heterotopic cardiac xenograft model, which hamster hearts were implanted into LEW rats. Despite the presence low titers rat anti-hamster lymphocytotoxic antibodies immediate rejection did not occur, suggesting that this model represented xenogeneic barrier moderate strength, compatible with close relationship two species. Cyclosporin A, doses approaching toxic levels 35 or 50 mg/kg/day for 14 days, prolonged function xenografts median survival times 21 and 11 respectively, contrast to 2 days untreated recipients. antibody response rats suppressed, even prolong graft survival. Only dose produced any significant alteration histological features xenografts. Although markedly between these closely related species, requirement virtually drug an do suggest will be value transplantation vascularized organ