Nebulised adrenaline in acute severe asthma: comparison with salbutamol.

摘要: Adrenaline may have beneficial effects in asthma addition to a direct beta-adrenoceptor mediated bronchodilatation, such as alpha-receptor reduction microvascular leakage and oedema, inhibition of bronchoconstrictor neural pathways. We compared the bronchodilator effect nebulised adrenaline (1 mg) with salbutamol (2.5 patients acute severe asthma. Eighteen admitted (mean peak expiratory flow 22% predicted) were randomised receive either or double-blind fashion and, after 15 min, changed alternative nebulisation determine if there was any additional bronchodilation. There no differences between increase PEF +/- SEM 99 20.5 L/min) (119 22.7 L/min). Heart rate fell each nebuliser difference treatments. PaO2 rose (0.5 0.15 kPa), but (-0.2 0.11 kPa). These results suggest that is effective beta-agonist without significant side-effects. The theoretical advantages conferred by alpha-agonist activity do not produce bronchodilation prevent fall due ventilation-perfusion mismatching.