Carbonic anhydrase IX (CAIX) is not an independent predictor of outcome in patients with clear cell renal cell carcinoma (ccRCC) after long-term follow-up.

摘要: Objective To evaluate carbonic anhydrase IX (CAIX) expression as an independent prognostic marker for clear cell renal carcinoma (ccRCC). With recent smaller studies showing conflicting results, we aimed to update our initial analysis in 2007 with additional 5-year follow-up. Patients and Methods We provided long-term follow-up of the same cohort used study (730 patients unilateral, sporadic ccRCC treated surgically between 1990 1999). Associations CAIX RCC death distant metastases were evaluated using Cox proportional hazards regression models. Results CAIX was expressed 708 (97.0%) specimens; 163 tumours (22.3%) had low (≤85%) 567 (77.7%) high (>85%) expression. There 483 deaths 265 RCC-specific deaths. The median 247 still under observation 13.8 years. Univariately, associated increased risk vs (hazard ratio 1.62; P < 0.001). Low not statistically significantly or after adjusting nuclear grade coagulative tumour necrosis. Conclusion After large cohort, results continue suggest that is ccRCC.