Principles of Small Molecule-DNA Recognition
作者： Stephen Neidle
DOI: 10.1016/B978-012369507-9.50006-6
关键词:
摘要: This chapter discusses principles of small molecule–DNA recognition. The task DNA sequence recognition has as its prerequisite knowledge the frequency occurrence a within defined length DNA. can be directly obtained from databank if entire target is known, which now case for human genome, and genomes in many other species, eukaryotic prokaryotic. In order direct readout to occur, an incoming molecule access base pairs via groove. orientation this group important since hydrogen bonding bases, hence readout, are predominantly directional interactions. edges bases Watson–Crick duplex have hydrogen-bonding potential that only partially satisfied by pairing itself therefore available ligand with complementarity. pattern hydrogen-bond donation acceptance built-in dependency.
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