Detection of Epstein-Barr virus DNA in cerebrospinal fluid for diagnosis of AIDS-related central nervous system lymphoma.
作者： J R Arribas , D B Clifford , C J Fichtenbaum , R L Roberts , W G Powderly
DOI: 10.1128/JCM.33.6.1580-1583.1995
关键词:
摘要: The diagnostic utility of Epstein-Barr virus (EBV) DNA detection in cerebrospinal fluid for the diagnosis central nervous system lymphoma was evaluated with two different PCR assays to test a collection samples from 24 AIDS patients disorders. A assay amplifying fragment BamHI-W region had highest clinical and analytic sensitivity. detected EBV 83% (5 6) pathologically proven primary 7% (1 16) controls autopsy-proven nonlymphomatous also one patient systemic involving probable lymphoma. consistently when involved meningeal surfaces. appears be useful AIDS-related lymphoma, but additional studies are required better define sensitivity understand significance positive absence
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