Sleep Disturbance and Risk of Active Disease in Patients With Crohn's Disease and Ulcerative Colitis

摘要: BACKGROUND & AIMS: Impairment of sleep quality is common in patients with inflammatory bowel diseases (IBDs) (eg, Crohn’s disease [CD] and ulcerative colitis [UC]), even during clinical remission. Sleep impairment can activate pathways. Few prospective studies have examined the role disturbance on risk relapse IBD. METHODS: We analyzed data from 3173 IBD (1798 remission at baseline) participating Colitis Foundation America Partners study, a longitudinal, Internet-based cohort. was measured using subset questions Patient Reported Outcomes Measurement Information Systems questionnaire. Disease activity assessed short Activity Index simple index for CD UC, respectively. Logistic regression used to identify predictors examine effect baseline among active 6 months. RESULTS: activity, depression, female sex, smoking, use corticosteroids or narcotics were associated enrollment. Among 1291 whose baseline, those impaired had 2-fold increase months (adjusted odds ratio, 2.00; 95% confidence interval, 1.45‐ 2.76); however, no observed UC (odds 1.14; 0.75‐1.74). These findings persisted number sensitivity analyses. CONCLUSIONS: an increased flares but not UC. indicate that evaluation treatment might improve outcomes.