Increased insulin-like growth factor-1 receptor mRNA expression predicts poor survival in immunophenotypes of early breast carcinoma

摘要: The biology of breast carcinoma shows a great variation, reflected by the recent classification phenotypes based on DNA microarrays or immunohistochemistry. aim this study was to determine prevalence insulin-like growth factor-1 receptor (IGF1R) in subtypes and impact outcome. We studied 197 consecutive patients stage I-II treated conservatively. Phenotypes were assessed basis expressions ER/PR, HER2, Ki67, p53, Bcl2, CK5/6 EGFR. Moreover, IGF1R expression (α-subunit β-phosphorylated/active form) evaluated immunohistochemistry, mRNA levels quantitative RT-PCR mutations direct sequencing. Overall, 40% (78/197) tumors luminal A, 24% (48/197) B, 19% (37/197) HER2-positive 17% (34/197) basal/triple-negative. Luminal A predominantly low grade, without necrosis, presenting older as ≤2-cm unilateral mass (all P ≤ 0.046). α-IGF1R overexpression observed more frequently (49%) cases, followed B (20%), area under curve (22%) basal/triple-negative cases (9%) (P = 0.01) with similar results for (53, 24, 13 10%, respectively) 0.038), but differences NS). High correlated poor patient survival among 0.004) (Kaplan-Meier; log-rank test). For overall survival, only histological grade emerged significant predictors 0.034; Cox regression). Increased implies poorer prognosis different subtypes, that may be associated lack responsiveness tamoxifen positive hormone status. Our highlight biological clinical relevance early provide knowledge assist treatment decision.