Advanced functional biocompatible polymeric matrix containing nano-compartments

作者: Srinivasa R. Raghavan , Matthew B. Dowling , Gregory F. Payne , Chao Zhu

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摘要: The present invention provides a novel biomaterial which is hybrid, self-assembling biopolymeric networked film that functionalized through hydrophobic interactions with vesicles loaded bioactive agents. compound polymeric network of hydrophobically modified chitosan scaffolds taken from solution and formed as solid film. This state capable the vesicles. include one or more lamellar structures forming nano-compartments are containing similar alternative active moieties within. Use results in degradation scaffold thereby releasing within scaffold. Application current occurs various delivery mechanisms routes administration will be described herein.

参考文章(123)
Horst Messinger, Chitosan-containing wound dressings ,(2005)
Buddy G. Kozen, Sara J. Kircher, Jose Henao, Fermin S. Godinez, Andrew S. Johnson, An Alternative Hemostatic Dressing: Comparison of CELOX, HemCon, and QuikClot Academic Emergency Medicine. ,vol. 15, pp. 74- 81 ,(2008) , 10.1111/J.1553-2712.2007.00009.X
William J. Curatolo, John R. Cardinal, Charles D. Ebert, Chitosan compositions for controlled and prolonged release of macromolecules ,(1985)
Alex Besonov, Dov Tamarkin, Meir Eini, Doron Friedman, Antibiotic kit and composition and uses thereof ,(2006)
Yi Liu, W. Lee Meyer, Gregory F. Payne, Xiao-Wen Shi, Chitosan-coated wires for biosensing ,(2009)
K. Fu, A.M. Klibanov, R. Langer, Protein stability in controlled-release systems. Nature Biotechnology. ,vol. 18, pp. 24- 25 ,(2000) , 10.1038/71875