Nitric Oxide Independent Activation of Guanylate Cyclase by YC-1 Causes Erectile Responses in the Rat
作者： H. MIZUSAWA , P. HEDLUND , J.D. BRIONI , J.P. SULLIVAN , K.-E. ANDERSSON
DOI: 10.1016/S0022-5347(05)65142-7
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摘要: Purpose: Activation of soluble guanylate cyclase with a subsequent increase in intracellular levels cyclic guanosine monophosphate is necessary for normal erection. In vascular tissue 3(5′-hydroxymethyl-2′-furyl-1-benzyl indazole (YC-1) (Abbott Laboratories, North Chicago, Illinois) has been shown to stimulate independent nitric oxide. We studied whether YC-1 modulates erectile responses the rat.Materials and Methods: The effects given intracavernously or intraperitoneally on intracavernous pressure were investigated rats. Functional neuronal endothelial oxide relaxations 3 × 10−6 M. 1-noradrenaline contracted preparations rat isolated corpus cavernosum.Results: Intracavernous (10 μmol. kg.−1) produced mean plus minus standard error 81 ± 17 cm. water (p <0.001) duration 7.1 3.3 minutes <0.001). int...
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