Prevalence and risk factors for clinically significant drug interactions with antiretroviral therapy

摘要: Study Objectives. To identify the prevalence and types of clinically significant drug interactions (CSDIs) in regimens patients with human immunodeficiency virus (HIV) infection who were receiving antiretroviral therapy to explore risk factors for these CSDIs. Design. Retrospective medical record review. Setting. Academic HIV specialty clinic. Patients. One hundred fifty-three randomly selected from May 1-September 30, 2006. Measurements Main Results. Data collected on patient demographics, date diagnosis, most recent viral load CD4+ count, Centers Disease Control Prevention classification, comorbid conditions. Patients' analyzed total using three resources. Logistic regression classification tree analysis used independent CSDI predictors. Clinically defined as that required a dosage adjustment or consisted combination is contraindicated due its high potential clinical adverse effects. Of 153 patients, at least one was found 41.2% their regimens: 34.6% interaction adjustment, 2.0% combination, 4.6% each CSDIs. In logistic model, independently associated CSDIs age older than 42 years (odds ratio [OR] 2.9, 95% CI 1.2–7.1), more conditions (OR 3.0, 1.4–6.6), treatment agents 2.4, 1.0–5.8), protease inhibitor 11.5, 4.2–31.2). When directly compared, prevalent among inhibitor–based nonnucleoside reverse transcriptase (p<0.001). Conclusion. are highly HIV-infected therapy. Knowledge may help clinicians recognize manage