Pituitary adenomas in childhood and adolescence.

摘要: Scientific advances are revealing the complexity of pituitary development, which is controlled by multiple transcription factors and signaling molecules. Unregulated cell growth, resulting in adenoma, usually sporadic results from monoclonal expansion a single mutated cell. However, some adenomas develop as part genetic syndrome. Prolactinoma most common hormonally active adenoma children. The non-functioning (non-secreting) second often stains positive for GH, PRL, and/or TSH. While Cushing disease, an ACTH-secreting commonly manifests weight gain with growth deceleration children, GH excess causes gigantism rapid, accelerated inappropriate height family. TSH secreting rare, biochemical analysis will show elevated thyroxine level non-suppressed or high Though natural history incidentalomas children unknown, adult practice guidelines established.