The Evolution of Neurofilament Light Chain in Multiple Sclerosis.

摘要: Multiple sclerosis (MS) is an autoimmune, inflammatory neurodegenerative disease of the central nervous system characterized by demyelination and axonal damage. Diagnosis prognosis are mainly assessed through clinical examination neuroimaging. However, more sensitive biomarkers needed to measure activity guide treatment decisions in MS. Prompt individualized management can reduce delay progression. Neurofilament Light chain (NfL), a neuron-specific cytoskeletal protein that released into extracellular fluid following injury, has been identified as biomarker Measurement NfL levels capture extent neuroaxonal damage, especially early stages disease. A growing body evidence shown cerebrospinal (CSF) serum be used reliable indicators response. More recently, facilitate for individuals with In this review, we discuss characteristics make highly informative depict available technologies its measurement. We further role CSF MS research settings. Finally, address some current topics debate regarding use practice examine possible directions may take future.