Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility

摘要: Pancreatic cancer has the worst prognosis among cancers due to difficulty of early diagnosis and its aggressive behavior. To characterize aggressiveness pancreatic on gene expression, xenografts transplanted into severe combined immunodeficient mice served as a panel for gene-expression profiling. As result profiling, adenylate cyclase-associated protein 1 (CAP1) was shown be overexpressed in all xenografts. The expression CAP1 73 cases recognized by immunohistochemical analyses. ratio CAP1-positive tumor cells clinical specimens correlated with presence lymph node metastasis neural invasion, also poor patients. Immunocytochemical analyses demonstrated that colocalized leading edge lamellipodia actin. Knockdown RNA interference resulted reduction lamellipodium formation, motility, invasion cells. This is first report demonstrating overexpression suggesting involvement behavior