Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

摘要: In vitro studies of Alzheimer’s disease are based on homogenously seeded neural cells. These reveal molecular pathway mechanism related to neurite degeneration, but they cannot analyze interactions between diseased and healthy Furthermore, the cell environment in homogenous is mostly reduced a two-dimensional surface. Here, we present novel, microfluidic culture method that combines (1) 3D micropatterning neurons with (2) local pa- thological states tau phosphorylation, characteristic feature Alzheimer brains. Using this novel Alzhei- mer model can accelerate about propagation processes future.