Tissue-Engineered Heart Valve with a Tubular Leaflet Design for Minimally Invasive Transcatheter Implantation

摘要: Transcatheter aortic valve implantation of (nonviable) bioprosthetic valves has been proven a valid alternative to conventional surgical in patients at high or prohibitive mortality risk. In this study we present the vitro proof-of-principle newly developed tissue-engineered heart for minimally invasive implantation, with ultimate aim adding unique advantages living tissue regeneration capabilities continuously developing transcatheter technologies. The tube-in-stent is fibrin-based tubular leaflet design. It consists construct sewn into self-expandable nitinol stent three commissural attachment points and along circumferential line so that it forms coaptating leaflets by collapsing under diastolic back pressure. constructs were molded fibrin human umbilical vein cells. After 3 weeks conditioning bioreactor, fully functional unobstructed openin...