A metabolically healthy obese phenotype in hispanic participants in the IRAS family study

摘要: Objective: Some obese individuals appear to be protected from developing type 2 diabetes mellitus and cardiovascular disease (CVD). This has led characterizing body size phenotypes based on cardiometabolic risk factors specifically as or overweight, metabolically healthy (MH) abnormal (MA) upon blood pressure, lipids, glucose homeostasis, inflammatory parameters. The aim of this study was measure the prevalence describe fat distribution across these in a minority population. Design Methods: Hispanic participants (N = 1054) IRAS Family Study were categorized into different phenotypes. Computed tomography (CT) abdominal scans evaluated for measures nonalcoholic fatty liver (NAFLD) distribution. Statistical models adjusting familial relationships estimated. Results: Seventy percent (70%) cohort overweight (32%) (38%). Forty-one (n 138) 19% 74) met criteria MH. Adjusted analyses showed MH phenotype associated with lower visceral adipose tissue (VAT) higher density (indicating content) (p 0.0005 p 0.0002, respectively), VAT but not 0.008 0.162, respectively) compared their MA counterparts. Odds NAFLD reduced (OR 0.34, 0.0007) obese. did differ between normal weight groups. Conclusions: These findings suggest that levels fat, despite overall increased total may defining feature obesity Americans.