Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
作者： Alexander Tsankov , Veronika Akopian , Alexander Meissner
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摘要: The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems kits generate lineage scorecard predicting the functionality suitability cell lines. In some aspects, methods generating comprises measuring gene expression plurality genes, such as pluripotent, ectoderm, mesoderm endoderm genes predict pluripotency differentiation potential line its and/or desired use. embodiments, can be compared with test accurately utility identify specific characteristics line, e.g., determine downstream applications, therapeutic use, drug screening, toxicity assays, into lineage, etc.
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