Catalytic asymmetric conjugate addition of various α-mercaptoketones to α,β-unsaturated N-acylated oxazolidin-2-ones with bifunctional organocatalyst
作者： Bo-Liang Zhao , Da-Ming Du
DOI: 10.1039/C4RA02400A
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摘要: A bifunctional squaramide catalysed enantioselective conjugate Michael addition reaction of various α-mercaptoketones to α,β-unsaturated N-acylated oxazolidinones under mild conditions has been developed. This catalytic afforded the corresponding adducts in good yields with high enantioselectivities (up 92% ee). is first example organocatalysed sulfa-Michael using as donors.
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