Regulation of Adenosine Receptor Subtypes and Cardiac Dysfunction in Human Heart Failure

摘要: A defective adenosine receptor-mediated autoregulation of the heart has been hypothesized to cause cardiomyopathy. Regulation gene expression four receptor subtypes A1, A2A, A2B, A3 and A1-mediated antiadrenergic signal transduction pathway studied in nonfailing failing human hearts. Gene myocardial A1-adenosine receptors inhibitory effects on cAMP levels or negative inotropic were not altered compared hearts, indicating that an impairment may be involved pathogenesis failure. Furthermore, A3-adenosine was unchanged while A2B mRNA detectable. However, A2A-adenosine increased by about 60% patients with dilated Thus, A2A-upregulation indicate a pathophysiological role for adds therefore increasingly complex picture molecular alterations