Involvement of MAPKs in ICAM-1 expression in glomerular endothelial cells in diabetic nephropathy.

摘要: Inflammatory processes are involved in the pathogenesis of diabetic nephropathy. The aim this study was to clarify role mitogen-activated protein kinase (MAPK) pathways for induction intercellular adhesion molecule-1 (ICAM-1) expression glomerular endothelial cells under conditions. We examined ICAM-1 kidneys experimental rats. Human (GE cells) were exposed normal glucose concentration, high concentration (HG), or mannitol (HM), and then phosphorylation 3 subfamilies determined using Western blot analysis. Next, evaluate involvement MAPKs HG- HM-induced expression, we preincubated GE with inhibitors ERK, p38 JNK 1h prior application mannitol. Expression increased glomeruli Both HG HM induced ERK1/2, cells. significantly attenuated by JNK. conclude that activation cascades may be