Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.
作者： Wanda K. O’Neal , Heshan Zhou , Núria Morral , Claire Langston , Robin J. Parks
DOI: 10.1007/BF03402113
关键词:
摘要: Background Certain gene therapy protocols may require multiple administrations of vectors to achieve therapeutic benefit to the patient. This may be especially relevant for vectors such …
biomedcentral.com
springer.com
sci-hub.se 参考文章(80)
F.L. Graham, L. Prevec, Adenovirus-based expression vectors and recombinant vaccines. Vaccines#R##N#New Approaches to Immunological Problems. ,vol. 20, pp. 363- 390 ,(1992) , 10.1016/B978-0-7506-9265-6.50022-1
Frank L. Graham, Ludvik Prevec, Manipulation of adenovirus vectors. Methods of Molecular Biology. ,vol. 7, pp. 109- 128 ,(1991) , 10.1385/0-89603-178-0:109
S Connelly, JM Gardner, RM Lyons, A McClelland, M Kaleko, Sustained expression of therapeutic levels of human factor VIII in mice Blood. ,vol. 87, pp. 4671- 4677 ,(1996) , 10.1182/BLOOD.V87.11.4671.BLOODJOURNAL87114671
J.M. Wilson, In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. Journal of Biological Chemistry. ,vol. 269, pp. 13695- 13702 ,(1994) , 10.1016/S0021-9258(17)36886-2
P Yeh, J F Dedieu, C Orsini, E Vigne, P Denefle, M Perricaudet, Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. Journal of Virology. ,vol. 70, pp. 559- 565 ,(1996) , 10.1128/JVI.70.1.559-565.1996
S C Wadsworth, H Zhou, A E Smith, J M Kaplan, Adenovirus vector-infected cells can escape adenovirus antigen-specific cytotoxic T-lymphocyte killing in vivo. Journal of Virology. ,vol. 71, pp. 5189- 5196 ,(1997) , 10.1128/JVI.71.7.5189-5196.1997
H Zhou, W O'Neal, N Morral, A L Beaudet, Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted. Journal of Virology. ,vol. 70, pp. 7030- 7038 ,(1996) , 10.1128/JVI.70.10.7030-7038.1996
Robert P. Wersto, Eugene R. Rosenthal, Prem K. Seth, N. Tony Eissa, Robert E. Donahue, Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins. Journal of Virology. ,vol. 72, pp. 9491- 9502 ,(1998) , 10.1128/JVI.72.12.9491-9502.1998
Sandeep K. Tripathy, Hugh B. Black, Eugene Goldwasser, Jeffrey M. Leiden, Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors Nature Medicine. ,vol. 2, pp. 545- 550 ,(1996) , 10.1038/NM0596-545
John F. Engelhardt, Leslie Litzky, James M. Wilson, Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Human Gene Therapy. ,vol. 5, pp. 1217- 1229 ,(1994) , 10.1089/HUM.1994.5.10-1217