MR imaging of microvasculature

摘要: An imaging technique is proposed in which the contrast correlated to morphology of capillaries and other small blood vessels. The based on measurements relaxation rates 1/T(2) 1/T*(2) before after injection a agent. image then formed by mapping quantity Q identical with delta R(2)/(delta R*(2))(2/3), where R(2) R*(2) are changes due If agent concentration sufficiently high, it shown that given approximately simple analytic formula involves only intrinsic properties vascular network rate diffusion. In particular, sensitive histologic vessel density. Theoretical predictions for be consistent experimental data obtained rat glioma model normal cerebral cortex. may useful characterizing tumor angiogenesis. Magn Reson Med 44:224-230, 2000.