Moisture-induced aggregation of lyophilized insulin
作者： Henry R. Costantino , Robert Langer , Alexander M. Klibanov
关键词:
摘要: … lyophilization and/or dissolution of insulin in alkaline media. … protein conformational mobility in the aggregation process. … during the alkaline dissolution process, presumably the B-…
springer.com
sci-hub.se 参考文章(30)
K. Geisen, H. Thurow, Stabilisation of dissolved proteins against denaturation at hydrophobie interfaces Diabetologia. ,vol. 27, pp. 212- 218 ,(1984) , 10.1007/BF00273809
Marilynn I. Schnepf, Protein-Water Interactions Biochemistry of Food Proteins. pp. 1- 33 ,(1992) , 10.1007/978-1-4684-9895-0_1
J Brange, L Langkjaer, Chemical stability of insulin. 3: Influence of excipients, formulation, and pH Acta pharmaceutica nordica. ,vol. 4, pp. 149- 158 ,(1992)
Mark C. Manning, Kamlesh Patel, Ronald T. Borchardt, Stability of Protein Pharmaceuticals Pharmaceutical Research. ,vol. 6, pp. 903- 918 ,(1989) , 10.1023/A:1015929109894
Jens Brange, Svend Havelund, Philip Hougaard, Chemical stability of insulin. 2. Formation of higher molecular weight transformation products during storage of pharmaceutical preparations. Pharmaceutical Research. ,vol. 9, pp. 727- 734 ,(1992) , 10.1023/A:1015887001987
Peter W. Riddles, Robert L. Blakeley, Burt Zerner, [8] Reassessment of Ellman's reagent Enzyme Structure Part I. ,vol. 91, pp. 49- 60 ,(1983) , 10.1016/S0076-6879(83)91010-8
BARRY V. FISHER, PATRICIA B. PORTER, Stability of bovine insulin Journal of Pharmacy and Pharmacology. ,vol. 33, pp. 203- 206 ,(2011) , 10.1111/J.2042-7158.1981.TB13758.X
A Klibanov, Enzymatic catalysis in anhydrous organic solvents Trends in Biochemical Sciences. ,vol. 14, pp. 141- 144 ,(1989) , 10.1016/0968-0004(89)90146-1
V. Sluzky, J. A. Tamada, A. M. Klibanov, R. Langer, Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 9377- 9381 ,(1991) , 10.1073/PNAS.88.21.9377
Stephen Brunauer, P. H. Emmett, Edward Teller, Adsorption of Gases in Multimolecular Layers Journal of the American Chemical Society. ,vol. 60, pp. 309- 319 ,(1938) , 10.1021/JA01269A023