The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception
作者： Michael W. Weiner , Dallas P. Veitch , Paul S. Aisen , Laurel A. Beckett , Nigel J. Cairns
DOI: 10.1016/J.JALZ.2013.05.1769
关键词:
摘要: The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing, longitudinal, multicenter study designed to develop clinical, imaging, genetic, and biochemical biomarkers for the early detection tracking of disease (AD). aimed enroll 400 subjects with mild cognitive impairment (MCI), 200 AD, normal control subjects; $67 million funding was provided by both public private sectors, including National Institute on Aging, 13 pharmaceutical companies, 2 foundations that support through Foundation Institutes Health. This article reviews all papers published since inception initiative summarizes results as February 2011. major accomplishments ADNI have been follows: (1) development standardized methods clinical tests, magnetic resonance imaging (MRI), positron emission tomography (PET), cerebrospinal fluid (CSF) in a setting; (2) elucidation patterns rates change CSF biomarker measurements subjects, MCI patients, AD patients. are consistent trajectories predicted β-amyloid cascade (Hardy, J Alzheimers Dis 2006;9(Suppl 3):151-3) tau-mediated neurodegeneration hypotheses whereas brain atrophy hypometabolism levels show but exhibit differing depending region severity; (3) assessment alternative diagnostic categorization. Currently, best classifiers combine optimum features from multiple modalities, MRI, [(18)F]-fluorodeoxyglucose-PET, biomarkers, tests; (4) AD. 42 tau, well amyloid PET may reflect earliest steps pathology mildly symptomatic or even nonsymptomatic leading candidates its preclinical stages; (5) improvement trial efficiency identification most likely undergo imminent future decline use more sensitive outcome measures reduce sample sizes. Baseline and/or MRI generally better than other were shown be efficient measures; (6) confirmation risk loci CLU, CR1, PICALM novel candidate loci; (7) worldwide impact establishment ADNI-like programs Europe, Asia, Australia; (8) understanding biology pathobiology aging, MCI, integration data stimulate research will resolve controversies about competing etiopathogenesis thereby advancing efforts find disease-modifying drugs AD; (9) infrastructure allow sharing raw processed without embargo interested scientific investigators throughout world. extended 2-year Grand Opportunities grant 2009 renewal (ADNI-2) October 2010 2016, enrollment additional 550 participants.
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elsevier.com参考文章(366)
Hidenao Fukuyama, Neuroimaging in mild cognitive impairment Rinshō shinkeigaku Clinical neurology. ,vol. 46, pp. 791- 794 ,(2006)
Simon J McBride, Cassandra E I Szoeke, Norm M Good, David Ames, Ralph N Martins, Colin L Masters, Paul T Maruff, Christopher C Rowe, Greg Savage, Kathryn A Ellis, A Web-based normative data tool for assessing cognitive performance in healthy older Australians The Medical Journal of Australia. ,vol. 194, ,(2011) , 10.5694/J.1326-5377.2011.TB02936.X
Hiroyuki Arai, [Alzheimer's disease neuroimaging initiative and mild cognitive impairment]. Rinshō shinkeigaku Clinical neurology. ,vol. 47, pp. 905- 907 ,(2007)
Shannon L Risacher, Kwangsik Nho, Li Shen, Shanker Swaminathan, Andrew J Saykin, Alzheimer’s Disease Neuroimaging Initiative, Sungeun Kim, The effect of reference panels and software tools on genotype imputation. american medical informatics association annual symposium. ,vol. 2011, pp. 1013- 1018 ,(2011)
Laurent Risser, François-Xavier Vialard, Robin Wolz, Darryl D. Holm, Daniel Rueckert, Simultaneous Fine and Coarse Diffeomorphic Registration: Application to Atrophy Measurement in Alzheimer’s Disease Medical Image Computing and Computer-Assisted Intervention – MICCAI 2010. ,vol. 13, pp. 610- 617 ,(2010) , 10.1007/978-3-642-15745-5_75
Prashanthi Vemuri, Heather J. Wiste, Stephen D. Weigand, David S. Knopman, Leslie M. Shaw, John Q. Trojanowski, Paul S. Aisen, Michael Weiner, Ronald C. Petersen, Clifford R. Jack, , Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease. Annals of Neurology. ,vol. 67, pp. 308- 316 ,(2009) , 10.1002/ANA.21953
James K Lui, Simon M Laws, Qiao-Xin Li, Victor L Villemagne, David Ames, Belinda Brown, Ashley I Bush, Karl De Ruyck, Jasmin Dromey, Kathryn A Ellis, Noel G Faux, Jonathan Foster, Christopher Fowler, Veer Gupta, Peter Hudson, Katrina Laughton, Colin L Masters, Kelly Pertile, Alan Rembach, Mira Rimajova, Mark Rodrigues, Christopher C Rowe, Rebecca Rumble, Cassandra Szoeke, Kevin Taddei, Tania Taddei, Brett Trounson, Vanessa Ward, Ralph N Martins, AIBL Research Group, None, Plasma Amyloid-β as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging Journal of Alzheimer's Disease. ,vol. 20, pp. 1233- 1242 ,(2010) , 10.3233/JAD-2010-090249
Wayne Latu, Alison M. Goate, David M. Holtzman, Anthony L. Hinrichs, Carlos Cruchaga, Sarah Bertelsen, John S.K. Kauwe, Kevin Mayo, Anne M. Fagan, Petra Nowotny, Alzheimer's Disease Neuroimaging Initiative, Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. Journal of Alzheimer's Disease. ,vol. 21, pp. 833- 842 ,(2010) , 10.3233/JAD-2010-091711
L. M. Rimol, I. Agartz, S. Djurovic, A. A. Brown, J. C. Roddey, A. K. Kahler, M. Mattingsdal, L. Athanasiu, A. H. Joyner, N. J. Schork, E. Halgren, K. Sundet, I. Melle, A. M. Dale, O. A. Andreassen, M. Weiner, L. Thal, R. Petersen, C. R. Jack, W. Jagust, J. Trojanowki, A. W. Toga, L. Beckett, R. C. Green, A. Gamst, W. Z. Potter, T. Montine, D. Anders, M. Bernstein, J. Felmlee, N. Fox, P. Thompson, N. Schuff, G. Alexander, D. Bandy, R. A. Koeppe, N. Foster, E. M. Reiman, K. Chen, J. Trojanowki, L. Shaw, V. M.- Y. Lee, M. Korecka, A. W. Toga, K. Crawford, S. Neu, D. Harvey, A. Gamst, J. Kornak, Z. Kachaturian, R. Frank, P. J. Snyder, S. Molchan, J. Kaye, R. Vorobik, J. Quinn, L. Schneider, S. Pawluczyk, B. Spann, A. S. Fleisher, H. Vanderswag, J. L. Heidebrink, J. L. Lord, K. Johnson, R. S. Doody, J. Villanueva-Meyer, M. Chowdhury, Y. Stern, L. S. Honig, K. L. Bell, J. C. Morris, M. A. Mintun, S. Schneider, D. Marson, R. Griffith, B. Badger, H. Grossman, C. Tang, J. Stern, L. deToledo-Morrell, R. C. Shah, J. Bach, R. Duara, R. Isaacson, S. Strauman, M. S. Albert, J. Pedroso, J. Toroney, H. Rusinek, M. J. de Leon, S. M. De Santi, P. M. Doraiswamy, J. R. Petrella, M. Aiello, C. M. Clark, C. Pham, J. Nunez, C. D. Smith, C. A. Given II, P. Hardy, S. T. DeKosky, M. Oakley, D. M. Simpson, M. S. Ismail, A. Porsteinsson, C. McCallum, S. C. Cramer, R. A. Mulnard, C. McAdams-Ortiz, R. Diaz-Arrastia, K. Martin-Cook, M. DeVous, A. I. Levey, J. J. Lah, J. S. Cellar, J. M. Burns, H. S. Anderson, M. M. Laubinger, G. Bartzokis, D. H. S. Silverman, P. H. Lu, R. Fletcher, F. Parfitt, H. Johnson, M. Farlow, S. Herring, A. M. Hake, C. H. van Dyck, M. G. MacAvoy, L. A. Bifano, H. Chertkow, H. Bergman, C. Hosein, S. Black, S. Graham, C. Caldwell, H. Feldman, M. Assaly, G.-Y. R. Hsiung, A. Kertesz, J. Rogers, D. Trost, C. Bernick, D. Gitelman, N. Johnson, M. Mesulam, C. Sadowsky, T. Villena, S. Mesner, P. S. Aisen, K. B. Johnson, K. E. Behan, R. A. Sperling, D. M. Rentz, K. A. Johnson, A. Rosen, J. Tinklenberg, W. Ashford, M. Sabbagh, D. Connor, S. Obradov, R. Killiany, A. Norbash, T. O. Obisesan, A. Jayam-Trouth, P. Wang, A. P. Auchus, J. Huang, R. P. Friedland, C. DeCarli, E. Fletcher, O. Carmichael, S. Kittur, S. Mirje, S. C. Johnson, M. Borrie, T.-Y. Lee, S. Asthana, C. M. Carlsson, S. G. Potkin, D. Highum, A. Preda, D. Nguyen, P. N. Tariot, B. A. Hendin, D. W. Scharre, M. Kataki, D. Q. Beversdorf, E. A. Zimmerman, D. Celmins, A. D. Brown, S. Gandy, M. E. Marenberg, B. W. Rovner, G. Pearlson, K. Blank, K. Anderson, A. J. Saykin, R. B. Santulli, N. Pare, J. D. Williamson, K. M. Sink, H. Potter, B. Ashok Raj, A. Giordano, B. R. Ott, C.-K. Wu, R. Cohen, K. L. Wilks, , Sex-dependent association of common variants of microcephaly genes with brain structure Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 384- 388 ,(2010) , 10.1073/PNAS.0908454107
Ben Schmand, Piet Eikelenboom, Willem A Van Gool, Alzheimer's Disease Neuroimaging Initiative, Value of Neuropsychological Tests, Neuroimaging, and Biomarkers for Diagnosing Alzheimer's Disease in Younger and Older Age Cohorts Journal of the American Geriatrics Society. ,vol. 59, pp. 1705- 1710 ,(2011) , 10.1111/J.1532-5415.2011.03539.X