Proposal for standard recommendations for prophylaxis of graft-versus-host disease in children. European Group for Blood and Marrow Transplantation (EBMT) Working Party Paediatric Diseases and the International Study Committee of the BFM family-subcommittee Bone Marrow Transplantation (IBFM-STG).

摘要: Great variations exist in the practices of graft-versus-host disease prophylaxis for children undergoing allogeneic stem cell transplantation. It was aim EBMT Working Party on Paediatric Diseases and International Study Group BFM-Family, subcommittee bone marrow transplantation (IBFM-SG) to define standard recommendation prevention GVHD. Thus a survey carried out among local representatives WP IBFM-SG members standards GVHD basing available literature data, discussion with colleagues their own experience. Presently majority regimen are centred CsA short course MTX addition some other immunosuppression (eg ATG or ALG) patients high risk severe The proposal defined different category patients: malignant who either transplanted from HLA matched sibling donors mismatched family (or volunteer unrelated donors) non might not benefit graft-versus-leukaemia effect having an donor donor). Homogeneous patient groups should provide better information optimise strategies reducing treatment related toxicity incidence relapse by increasing GVL effect.