Is there a correlation between biophotonical, biochemical, histological, and visual changes in the cartilage of osteoarthritic knee-joints?

摘要: The aim of this study was to detect characteristic structural changes in the cartilage composition osteoarthritis (OA), hereby improving arthroscopic identification pathology by use a non-destructive technique - NIRS (Near-Infrared Spectroscopy). 682 samples out 25 knees with OA were classified visually, using ICRS system, biophotonically, histologically (n = 66), Score Mankin and Otte, biochemically 616), determining content glycosaminoglycan (GAG) hydroxyproline (HP). Significant correlations found between biophotonical, histological, biochemical visual characteristics lesions. values corresponded GAG, HP Otte. data show that structure articular influence optical properties can be measured objectively NIRS. ease during arthroscopy, quick response nature make it promising addition assessment disease intervention