Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels.

摘要: The mammalian family of two-pore domain K+ (K2P) channel proteins are encoded by 15 KCNK genes and subdivided into six subfamilies on the basis sequence similarities: TWIK, TREK, TASK, TALK, THIK, TRESK. K2P channels expressed in cells throughout body have been implicated diverse cellular functions including maintenance resting potential regulation excitability, sensory transduction, ion transport, cell volume regulation, as well metabolic apoptosis. In recent years isoforms identified important targets several widely employed drugs, including: general anesthetics, local neuroprotectants, anti-depressants. An goal future studies will be to identify drug actions isoform selectivity. This facilitated characterization native isoforms, their pharmacological properties tissue-specific expression patterns. To this end present review examines biophysical, pharmacological, functional characteristics cloned compares information with limited data available for order determine criteria which may useful identifying ionic currents mediated investigating characteristics.