Human Trophoblast-Uterine Immunological Interactions

摘要: Human implantation is accompanied by extensive invasion of uterine tissue trophoblast cells. Besides anchoring the placenta to uterus, these cells also perform important function converting decidual spiral arteries from highly resistant vessels into flaccid sinusoidal tubes that are no longer responsive vasoconstrictive influences, thus allowing maintenance an adequate blood flow fetoplacental unit under all physiological conditions (1). Normal pregnancy depends on this vascular adaptation trophoblast, without which a variety obstetrical problems, such as preeclampsia, intrauterine growth retardation, or still birth, will result (2). The factors control not known, but likely be contributed matrix proteins encountered en route during its migration. In chapter we focus potential immunological paraimmunological processes could take place between and population oflarge granular lymphocytes (LGL) present in decidua because there many characteristics two cell types suggest they able interact with each other.