Hippocampal D1-but not D2-like dopamine receptors modulate the phosphorylation of ERK in food deprivation-induced reinstatement of morphine in extinguished rats.

摘要: Reinstatement to drug abuse is the most challenging issue in treatment of addiction. Thus, knowledge involved neurobiological mechanisms reinstatement a fundamental necessity. There substantial and crucial evidence that dopamine implicated motivational processes such as relapse. Our behavioral results reported administration receptor antagonists inhibited morphine food-deprived rats. Previous studies have indicated ERK pathway plays critical role cellular responses stress reward. Therefore, purpose current study was evaluate effect intra-dentate gyrus on phosphorylation hippocampal phase reward All groups animals passed conditioned place preference were bilaterally given different doses D1- or D2-like compounds (0.25, 1 4 μg/0.5 μl) into dentate gyrus. Immediately after phase, each animal euthanized, hippocampi immediately dissected. Then, p-ERK/ERK ratio evaluated using Western blot analysis. The principal findings this demonstrated highest dose D1-like antagonist could enhance rats while D2-Like failed change ratio.