Blockade of Virus Infection by Human CD4+ T Cells Via a Cytokine Relay Network

摘要: CD4 + T cells directly participate in bacterial clearance through secretion of proinflammatory cytokines. Although viral relies heavily on CD8 cell functions, we sought to determine whether human could also influence cytokine secretion. We found that IFN-γ and TNF-α, secreted by IL-12-polarized Th1 cells, displayed potent antiviral effects against a variety viruses. TNF-α acted inhibit hepatitis C virus replication an vitro replicon system, neutralization both cytokines was required block the activity cells. exerted vesicular stomatitis infection, but this case, functional type I IFN receptor required. Thus, cases combination indirectly IFN-α/β receptor. These results highlight importance regulating responses acting direct indirect manner.